Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females

C-type natriuretic peptide and vascular remodeling.

Natriuretic Peptide Type-B Gene

The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as determined by ribonuclease protection analyses. Initiation of transcription was 31...

Biomarker for Cardiomyopathy-B-Type Natriuretic Peptide

Cardiomyopathy is cardiac condition in which the normal muscular function of the myocardium has been altered by a variety of etiologies. Atherosclerotic coronary artery disease is the most common cause of cardiomyopathy in North America and Europe. Idiopathic cardiomyopathy is the second most common cause, although this may partially include undiagnosed etiologies such as viral infection, drug ...

B-type natriuretic peptide: where are we?

who presented at an A&E department with acute dyspnea and showed that a BNP > 100 pg/mL had a sensitivity of 90% and a specificity of 70% in differentiating dyspnea of cardiac origin from that of other causes. The diagnostic accuracy rose from 74 to 81% when BNP levels were added to clinical criteria7. The diagnostic power of BNP was greater than that of either the Framingham criteria or the Na...

B-type natriuretic peptide and cirrhosis progression.

Brain natriuretic peptide (BNP) is used as a marker of cardiac dysfunction to predict heart failure mortality. The significance of the prognostic ability of BNP for liver cirrhosis remains unknown, although the levels of BNP seen in cirrhosis are high. We aimed to determine whether the BNP level is related to the stage of cirrhosis and could serve as a prognostic marker of cirrhosis (predict th...